Rolesets - downregulate

downregulate

downregulate.01 - reduce a cellular response to a molecular stimulus

DOWNREGULATE-V NOTES: Created for Bio-AMR annotations.

Aliases:

downregulate (v.)
downregulation (n.)

Roles:

ARG0-PAG: intentional agent of downregulation (e.g. scientist)
ARG1-PPT: thing downregulated (e.g. protein or another molecule)
ARG2-MNR: instrument (e.g. enzyme)

downregulate-v: example with instrument

The two - handed E box binding zinc finger protein SIP1ARG2
downregulatesrel
E - cadherinARG1
and induces invasion .

downregulate-v: with intentional agent

In this studyARGM-LOC
,
weARG0
downregulatedrel
miR-34s in human mesothelial cellsARG1
to investigate the cellular effect of miR-34 knockdownARGM-PRP
.

downregulation-n

Some receptor agonists may cause
downregulationrel
of their respective receptor(s )ARG1
,